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Mechanistic experiments disclosed compound forty eight induced S-stage mobile cycle arrest and apoptosis in CCRF-CEM cells. The structure–action relationship (SAR) Investigation indicated that a five,6-dimethoxy moiety along with a two-ethyl ester group about the indole scaffold were being essential for great antiproliferative potency, highlighti
With this method, a number of bifunctional products were prepared in very good to excellent yields. Both of these two examples included expensive rhodium catalyst. To handle this concern, they [27] explored a synergistic cobalt and copper catalytic program making use of an analogous approach to provide 1H-indazoles 35 (Plan twelve). With this funct